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At 24 several hours the plasma amounts of sildenafil had been nonetheless roughly 200 ng/mL, when compared with about 5 ng/mL when sildenafil was dosed by itself. That is in line with ritonavir's marked effects with a wide selection of P450 substrates. VIAGRA had no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERA